C-reactive protein. Structural biology, gene expression, and host defense function

Academic Article


  • Over the past few years substantial insight was gained into the biology and biochemistry of human C-reactive protein (CRP). X-ray crystallography in conjunction with mutational analyses, generated the three-dimensional structure of the protein and indicated the topology and structure of ligand-binding sites. Using human CRP transgenic mice infected with Streptococcus pneumoniae, we obtained data that clearly established CRP as an important host defense molecule. Studies using the same mice revealed a previously unknown testosterone-dependence of constitutive expression of human CRP. In this article we provide a brief overview of these recent findings.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Szalai AJ; Agrawal A; Greenhough TJ; Volanakis JE
  • Start Page

  • 127
  • End Page

  • 136
  • Volume

  • 16
  • Issue

  • 2