Studies of the protective effect of ribose in myocardial ischaemia by using 31P-nuclear-magnetic-resonance spectroscopy

Academic Article

Abstract

  • It has been shown that the presence of ribose both throughout ischaemia and during re-perfusion significantly increases the level of ATP in cardiac tissue after ischaemia. As new steady state levels of ATP are established within 30 min of re-perfusion it is unlikely that this is due to an increase in synthesis de novo of adenine nucleotides. The mechanism underlying the action of ribose does not alter the development of acidosis during ischaemia and therefore appears to be independent of any effect on anaerobic glycolysis.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Chatham JC; Challiss RAJ; Radda GK; Seymour AML
  • Start Page

  • 885
  • End Page

  • 886
  • Volume

  • 13
  • Issue

  • 5