Protein O-GlcNAcylation and cardiovascular (patho)physiology

Academic Article

Abstract

  • © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this minireview are to summarize our current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O-GlcNAc cycling is critical for normal function of the cardiovascular system.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Marsh SA; Collins HE; Chatham JC
  • Start Page

  • 34449
  • End Page

  • 34456
  • Volume

  • 289
  • Issue

  • 50