Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy a randomized clinical trial

Academic Article


  • IMPORTANCE: Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44%to 55%; longer cooling and deeper cooling are neuroprotective in animal models.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 7753035
  • Author List

  • Shankaran S; Laptook AR; Pappas A; McDonald SA; Das A; Tyson JE; Poindexter BB; Schibler K; Bell EF; Heyne RJ
  • Start Page

  • 2629
  • End Page

  • 2639
  • Volume

  • 312
  • Issue

  • 24