To the Editor: The study by Fowler et al. (March 5 issue)1 on the outcome of congenital cytomegalovirus (CMV) infection according to whether the infants' mothers had primary or recurrent disease during pregnancy provides valuable data for use in counseling parents. One of the criteria the authors used to distinguish between primary and recurrent infection was the presence of CMV-specific IgM antibodies in the mother during pregnancy. Among 132 infants in the primary-infection group, the assignment of 58 to the group was based solely on the presence of a CMV-specific IgM antibody in the mother, without documentation of IgG sero-conversion… © 1992, Massachusetts Medical Society. All rights reserved.