Predicting conversion to dementia from amnestic mild cognitive impairment using neuropsychological tests

Academic Article

Abstract

  • The ability to predict which individuals with mild cognitive impairment (MCI) will eventually develop Alzheimer's disease (AD) would be a valuable clinical tool. This study aimed to predict conversion from MCI to AD within two years using baseline neuropsychological measures from 49 individuals with amnestic MCI. Stepwise discriminant function analysis including Dementia Rating Scale Initiation/Perseveration and Wechsler Memory Scale, 3rd Edition, Visual Reproduction Percent Retention scores correctly classified risk for conversion to AD in 85.7% of the sample, identifying them as either MCI Nonconverters or AD Converters. Establishing cutoff scores below 37 for DRS Initiation/ Perseveration and below 26 for Visual Reproduction Percent Retention correctly classified 87.8% of the sample as MCI Nonconverters or AD Converters with regard to risk for conversion to AD. These results suggest that commonly used neuropsychological measures possess the predictive ability to determine risk of conversion to dementia in MCI patients within 1-2 years' time.
  • Authors

    Author List

  • Netson KL; Griffith HR; Marson DC
  • Start Page

  • 127
  • End Page

  • 133
  • Volume

  • 12