Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-α mRNA expression in human monocytes by allicin

Academic Article

Abstract

  • Chronic inflammation associated with tumor necrosis factor (TNF)-α and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF-α. We show the augmented expression of TNF-α mRNA in MTB-infected monocytes by cellular activation and ROS was suppressed by allicin in a dose-dependent manner. Also, allicin enhanced the glutathione peroxidase activity, which correlated inversely with the downregulation of ROS and TNF-α in MTB-infected monocytes. Hence, allicin may prove to be a valuable natural antioxidant in combating tuberculosis. © 2006.
  • Digital Object Identifier (doi)

    Author List

  • Hasan N; Yusuf N; Toossi Z; Islam N
  • Start Page

  • 2517
  • End Page

  • 2522
  • Volume

  • 580
  • Issue

  • 10