Type i interferons: Key players in normal skin and select cutaneous malignancies

Academic Article

Abstract

  • Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. Type I Interferons include IFN- and IFN-β. Currently, IFN- has numerous approved antitumor applications, including malignant melanoma, in which IFN- has been shown to increase relapse free survival. Moreover, IFN- has been successfully used in the intralesional treatment of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). In spite of these promising clinical results; however, there exists a paucity of knowledge on the precise anti-tumor action of IFN-/β at the cellular and molecular levels in cutaneous malignancies such as SCC, BCC, and melanoma. This review summarizes current knowledge on the extent to which Type I IFN influences proliferation, apoptosis, angiogenesis, and immune function in normal skin, cutaneous SCC, BCC, and melanoma. © 2014 Aimen Ismail and Nabiha Yusuf.
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    Digital Object Identifier (doi)

    Author List

  • Ismail A; Yusuf N
  • Volume

  • 2014