Differential roles of T-cell subsets in regulation of ultraviolet radiation induced cutaneous photocarcinogenesis

Academic Article

Abstract

  • Ultraviolet (UV) radiation, in particular the midwavelength range (UVB; 290-320 nm), is one of the most significant risk factors for the development of nonmelanoma skin cancer. UVB radiation-induced immunosuppression, which occurs in both humans and laboratory animals, contributes to their pathogenesis. However, there are conflicting reports on the relative role of CD4 and CD8 T cells in UVB induced skin cancer. The purpose of this study was to delineate the contribution of these two cell subpopulations to UVB induced immunosuppression and tumor development using C3H/HeN (WT), CD4 knockout (CD4 ) and CD8 knockout (CD8 ) mice. We observed that UVB induced skin carcinogenesis was retarded in terms of number of tumors per group, tumor volume and percentage of mice with tumors, in mice deficient in CD4 T cells compared with wild-type mice, whereas significantly greater (P < 0.05) numbers of tumors occurred in CD8 mice. These results indicate that, CD4 T cells promote tumor development while CD8 T cells have the opposite effect. Further, we found that CD4 T cells from tumor-bearing mice produced interleukin (IL)-4, IL-10, and IL-17 whereas CD8 T cells produced interferon-γ. Manipulation of T-cell subpopulations that are induced by UVB radiation could be a means of preventing skin cancers caused by this agent. © 2010 The American Society of Photobiology. + + -/- -/- + -/- + + + +
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    Digital Object Identifier (doi)

    Author List

  • Nasti TH; Iqbal O; Tamimi IA; Geise JT; Katiyar SK; Yusuf N
  • Start Page

  • 387
  • End Page

  • 398
  • Volume

  • 87
  • Issue

  • 2