ACTION SPECTRUM STUDIES FOR INDUCTION OF IMMUNOLOGIC UNRESPONSIVENESS TO DINITROFLUOROBENZENE FOLLOWING IN VIVO LOW DOSE ULTRAVIOLET RADIATION

Academic Article

Abstract

  • Abstract— Topical application of the contact sensitizer dinitrofluorobenzene to the skin of C3H mice previously exposed in vivo to low doses of UVB radiation from FS20 sun lamps resulted in the acquisition of antigen‐specific unresponsiveness to that hapten. When narrow band radiation at various wavelengths between 260 and 320 nm was employed, increasing doses of radiation were found to produce increasing amounts of immunosuppression. Construction of an action spectrum curve revealed that radiation between 260 and 300 nm was most efficient in producing unresponsiveness. Wavelengths above 300 nm were much less efficient than those below 300 nm. These results indicate that there are major differences in the effectiveness of various components of the short and middle wavelength UV spectrum in eliciting immunologic unresponsiveness to a topically administered hapten. Potential chromophores for this UVB‐induced immunosuppressive effect include DNA and urocanic acid. Copyright © 1985, Wiley Blackwell. All rights reserved
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    Digital Object Identifier (doi)

    Author List

  • Elmets CA; LeVine MJ; Bickers DR
  • Start Page

  • 391
  • End Page

  • 397
  • Volume

  • 42
  • Issue

  • 4