MODULATION OF INTERFERON‐GAMMA‐INDUCED HLA‐DR EXPRESSION ON THE HUMAN KERATINOCYTE CELL LINE SCC‐13 BY ULTRAVIOLET RADIATION

Academic Article

Abstract

  • Cell surface expression of major histocompatibility determinants on epidermal keratinocytes is a characteristic feature of a number of inflammatory dermatoses and in all likelihood is caused by diffusion of human leukocyte antigen (HLA)‐DR‐inducing cytokines from cells present in the dermal mononuclear cell infiltrate. Many of these same disorders respond to ultraviolet(UV) radiation phototherapy. Using the human SCC‐13 keratinocyte cell line as a model, UV radiation was found to inhibit interferon‐gamma‐induced HLA‐DR expression. Inhibition correlated closely with decreased steady‐state levels of HLA‐DR mRNA. These findings provide evidence that the therapeutic effect of UV radiation phototherapy may be mediated by its capacity to down‐regulate cytokine‐induced keratinocyte HLA‐DR expression. Copyright © 1993, Wiley Blackwell. All rights reserved
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Khan IU; Boehm KD; Elmets CA
  • Start Page

  • 285
  • End Page

  • 290
  • Volume

  • 57
  • Issue

  • 2