Chlorine-induced cardiopulmonary injury

Academic Article

Abstract

  • Chlorine (Cl ) is utilized worldwide for a diverse range of industrial applications, including pulp bleaching, sanitation, and pharmaceutical development. Though Cl has widespread use, little is known regarding the mechanisms of toxicity associated with Cl exposure, which occurs during industrial accidents or acts of terrorism. Previous instances of Cl exposure have led to reported episodes of respiratory distress that result in high morbidity and mortality. Furthermore, studies suggest that acute Cl exposure also results in systemic vascular injury and subsequent myocardial contractile dysfunction. Here, we review both lung and cardiac pathology associated with acute Cl inhalation and discuss recently published data that suggest that mitochondrial dysfunction underlies the pathogenesis of Cl -induced toxicity. Last, we discuss our findings that suggest that upregulation of autophagy protects against Cl -induced lung inflammation and can be a potential therapeutic target for ameliorating the toxic effects of Cl exposure. 2 2 2 2 2 2 2 2 2
  • Digital Object Identifier (doi)

    Author List

  • Carlisle M; Lam A; Svendsen ER; Aggarwal S; Matalon S
  • Start Page

  • 159
  • End Page

  • 167
  • Volume

  • 1374
  • Issue

  • 1