Comparison of the hemodynamic effects of endothelin-1 and big endothelin-1 in the rat

Academic Article


  • We compared the hemodynamic effects of continuous i.v. infusion of endothelin-1 and big endothelin-1 in anesthetized rats. Big endothelin-1 was fivefold less potent than endothelin-1 in decreasing cardiac output, heart rate, and stroke volume. However, big endothelin-1 produced a significantly larger increase in mean arterial pressure compared to endothelin-1 at doses that produced identical decreases in cardiac output. These findings support the hypothesis that the hypertensive effects of big endothelin-1 and endothelin-1 are produced by differential effects on systemic vascular resistances. © 1991.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Pollock DM; Opgenorth TJ
  • Start Page

  • 1122
  • End Page

  • 1126
  • Volume

  • 179
  • Issue

  • 2