Cholinergic receptors regulate a voltage-insensitive but Na+-dependent calcium influx pathway in salivary acinar cells

Academic Article

Abstract

  • The calcium-sensitive fluorescent probe, quin 2, was employed to investigate the cholinergic receptor regulation of cytosolic free calcium concentration ([Ca2+]i) in isolated rat submandibular acinar cells. Cholinergic receptor stimulation results in a marked and sustained elevation [Ca2+]i. The major component of this response is shown to be due to activation of a calcium influx pathway. There is no evidence in K+-depolarized cells of any voltage-gated calcium influx. Acetylcholine failed to activate the calcium influx pathway in cells bathed in Na+-free solutions. The cholinergic receptors thus regulate a voltage-insensitive but Na+ dependent transport system for calcium entry in submandibular acinar cells. © 1987.
  • Published In

  • FEBS Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Morris AP; Fuller CM; Gallacher DV
  • Start Page

  • 195
  • End Page

  • 199
  • Volume

  • 211
  • Issue

  • 2