IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms

Academic Article

Abstract

  • The transcription factor Tbet is critical for the differentiation of Th1 CD4 T cells and is associated with the induction of multiple autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vitro and in vivo in a cell-intrinsic manner, and that in fact, Tbet is not necessary for EAE induction. Moreover, we find that IFNγ inhibits the production of IL-17A and IL-17F in a STAT1-dependent, Tbet-independent manner. These findings illustrate multiple mechanisms utilized by developing Th1 cells to silence the Th17 program. © 2013 .
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Yeh WI; McWilliams IL; Harrington LE
  • Start Page

  • 20
  • End Page

  • 27
  • Volume

  • 267
  • Issue

  • 1-2