Saccharomyces cerevisiae polymerase ζ functions in mitochondria

Academic Article

Abstract

  • The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria. Copyright © 2006 by the Genetics Society of America.
  • Published In

  • Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Zhang H; Chatterjee A; Singh KK
  • Start Page

  • 2683
  • End Page

  • 2688
  • Volume

  • 172
  • Issue

  • 4