PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA.

Academic Article

Abstract

  • The common denominator of neurodegenerative diseases, which mainly affect humans, is the progressive death of neural cells resulting in neurological and cognitive deficits. Astroglial cells are the central elements of the homoeostasis, defence and regeneration of the central nervous system, and their malfunction or reactivity contribute to the pathophysiology of neurodegenerative diseases. Pathological remodelling of astroglia in neurodegenerative context is multifaceted. Both astroglial atrophy with a loss of function and astroglial reactivity have been identified in virtually all the forms of neurodegenerative disorders. Astroglia may represent a novel target for therapeutic strategies aimed at preventing and possibly curing neurodegenerative diseases.
  • Published In

  • Opera Med Physiol  Journal
  • Keywords

  • Alzheimer’s disease, Amyotrophic lateral sclerosis, Astroglia, Huntington disease, Neurodegenerative diseases, Neuroglia, Neurology
  • Author List

  • Verkhratsky A; Zorec R; Rodriguez JJ; Parpura V
  • Start Page

  • 13
  • End Page

  • 22
  • Volume

  • 1