Changes in the morphology and proliferation of astrocytes induced by two modalities of chemically functionalized single-walled carbon nanotubes are differentially mediated by glial fibrillary acidic protein

Academic Article

Abstract

  • Alterations in glial fibrillary acidic protein (GFAP) levels accompany the changes in the morphology and proliferation of astrocytes induced by colloidal solutes and films of carbon nanotubes (CNTs). To determine if GFAP is required for the effects of CNTs on astrocytes, we used astrocytes isolated from GFAP null mice. We find that selected astrocytic changes induced by CNTs are mediated by GFAP, i.e., perimeter, shape, and cell death for solutes, and proliferation for films. © 2014 American Chemical Society.
  • Published In

  • Nano Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Gottipati MK; Bekyarova E; Brenner M; Haddon RC; Parpura V
  • Start Page

  • 3720
  • End Page

  • 3727
  • Volume

  • 14
  • Issue

  • 7