Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity

Academic Article


  • Ingestion of killed cells of a highly cariogenic strain of Streptococcus mutans induced specific antibodies in both saliva and milk but not in serum of gnotobiotic rats. These antibodies were associated with the immunoglobulin A class. When infected with Streptococcus mutans, orally immunized animals developed significantly fewer carious lesions than nonimmunized infected controls.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Michalek SM; McGhee JR; Mestecky J; Arnold RR; Bozzo L
  • Start Page

  • 1238
  • End Page

  • 1240
  • Volume

  • 192
  • Issue

  • 4245