Oral-parenteral immunization leads to the appearance of IgG auto-anti-idiotypic cells in mucosal tissues

Academic Article


  • The appearance of plasma cells, specific for antigen or autologous idiotypic antibody, in rabbits immunized systemically, orally, or orally-systemically was determined using immunofluorescence techniques. Oral or parenteral immunizations alone did not lead to the appearance of anti-idiotypic cells in mucosal tissues, although IgA antigen-binding cells were observed in these sites after the oral administration of antigen. However, when rabbits were primed with orally administered antigen, followed by a regimen of concurrent oral-parenteral immunizations, IgG anti-idiotypic plasma cells were demonstrated in mucosal lymphoid tissues. © 1981.
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    Digital Object Identifier (doi)

    Author List

  • Jackson S; Mestecky J
  • Start Page

  • 498
  • End Page

  • 502
  • Volume

  • 60
  • Issue

  • 2