Shared Idiotypes Among Anti‐Albumin Antibodies of Different Species

Academic Article


  • A system designed to detect plasma cells that produce antibodies directed at autologous idiotypic determinants of anti‐human serum albumin (HSA) antibodies in rabbits was used to determine whether anti‐HSA antibodies of horse, goat, swine and chicken origin were cross‐reactive with rabbit antibodies of the same specificity. Fluorochrome‐tagged anti‐HSA preparations of these diverse species were used to stain splenic plasma cells of HSA‐immunized rabbits and a similarly immunized chicken. The degree of idiotypic cross‐reactivity, as detected by binding of anti‐HSA antibodies to anti‐idiotype within plasma cells of HSA‐immunized animals, was sometimes equal to autologous staining. However chicken anti‐Has, the most phylogenetically distant idiotype examined, was demonstrably less cross‐reactive than that obtained from the other species. Likewise, chicken plasma cells usually did not bind mammalian anti‐HSA antibodies to an appreciable degree, as compared with autologous staining. These findings provide evidence for serologic and possibly structural similarities of antibodies of the same specificity from different species. Copyright © 1981, Wiley Blackwell. All rights reserved
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  • Start Page

  • 31
  • End Page

  • 38
  • Volume

  • 14
  • Issue

  • 1