Role of hepatocytes in the uptake of IgA and IgA-containing immune complexes in mice

Academic Article

Abstract

  • The role of parenchymal and nonparenchymal mouse liver cells in the uptake of polymeric IgA (pIgA) and pIgA-containing immune complexes (IC) of low mol. wt (< 1 × 106) was studied. As detected by immunofluorescence and immunoelectron microscopy, pIgA were bound on the surface of isolated hepatocytes. Following the injection of radiolabeled pIgA or pIgA-IC into mice, the total radioactivity recovered from isolated liver cells was preferentially associated with parenchymal cells. The ability to inhibit the transport of pIgA and plgA-IC by pIgA of an irrelevant specificity suggests that pIgA-IC and pIgA are bound and transported by the same mechanism. These results indicate that mouse hepatocytes are involved in the uptake and hepatobiliary transport of pIgA and plgA-IC of low mol. wt. © 1988.
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    Digital Object Identifier (doi)

    Author List

  • Phillips JO; Kazuo K; Epps JM; Russell MW; Mestecky J
  • Start Page

  • 873
  • End Page

  • 879
  • Volume

  • 25
  • Issue

  • 9