Immunoglobulin isotype distribution of locally produced autoantibodies to collagen type I in adult periodontitis: Relationship to periodontal treatment

Academic Article


  • Abstract Production of antibodies to collagen type I was analyzed by means of an enzyme‐linked immunospot (ELISPOT) assay in patients with chronic adult periodontitis (AP) before and after periodontal hygiene treatment. Anti‐collagen type I antibody‐secreting cells were found among mononuclear cells enzymatically eluted from inflamed gingiva in 9 of 15 patients with untreated AP and in 4 of 14 hygiene‐treated patients with a varied isotype distribution. A notably high prevalence of IgG and IgM isotypes was observed for the anti‐collagen antibodies in untreated patients. With wide variation, chronic AP was characterized by a high frequency of spontaneous IgG and low numbers of IgA and IgM‐producing cells. Periodontal hygiene treatment significantly reduced the number of IgA and IgM‐secreting cells. Although AP is not an autoimmune disease in the accepted sense, our results indicate that local autoimmune reactions to collagen type I are common in untreated AP, implying an interplay between periodontal infection and autoimmunity. Copyright © 1991, Wiley Blackwell. All rights reserved
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    Digital Object Identifier (doi)

    Author List

  • Jonsson R; Pitts A; Lue C; Gay S; Mestecky J
  • Start Page

  • 703
  • End Page

  • 707
  • Volume

  • 18
  • Issue

  • 9