Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes

Academic Article

Abstract

  • We have investigated the mechanisms involved in the clearance of viral infection at the epithelium level by analyzing the activity of influenza virus-specific cytotoxic T lymphocytes (CTL) against virus-infected CMT-93 intestinal epithelial cells. Epithelial cells infected with live influenza virus effectively present viral antigens and were lysed by both homotypic and heterotypic influenza virus-specific CD8+ T cells. These results shed new light on the control of viral infection through the elimination of virus-infected epithelial cells by virus-specific CTL and demonstrate that CMT-93 cells furnish an appropriate model for in vitro evaluation of CTL activity against virus-infected epithelial cells.
  • Published In

    Author List

  • Nguyen HH; Boyaka PN; Moldoveanu Z; Novak MJ; Kiyono H; McGhee JR; Mestecky J
  • Start Page

  • 4534
  • End Page

  • 4536
  • Volume

  • 72
  • Issue

  • 5