Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function

Academic Article

Abstract

  • Single cell studies have identified intraclonal heterogeneity of cytokine production by activated T cells. To investigate implications of cytokine heterogeneity for cell fate, an interleukin (IL)-2 promoter-green fluorescent protein (GFP) reporter transgenic model was developed to track IL-2+ and IL-2- T cells during differentiation from naive precursors. Antigen-activated IL-2+ and IL-2- cells had comparable proliferative capacities in primary responses. However, T cells that expressed IL-2 in primary responses demonstrated enhanced antigenic sensitivity and increased expression of effector cytokines in secondary responses in vitro and in vivo. Thus, heterogeneity of activation during a primary response translates into heterogeneous secondary responses, in which enhanced memory/effector function is linked to cells that previously exceeded an activation threshold associated with IL-2 gene transcription.
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • Saparov A; Wagner FH; Zheng R; Oliver JR; Maeda H; Hockett RD; Weaver CT
  • Start Page

  • 271
  • End Page

  • 280
  • Volume

  • 11
  • Issue

  • 3