Subsets of ATP-sensitive potassium channel (K ATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of sur expression

Academic Article

Abstract

  • Gap junctional intercellular communication (GJIC) regulates cellular homeostasis by propagating signaling molecules, exchanging cellular metabolites, and coupling electrical signals. In cancer, cells exhibit altered rates of GJIC which may play a role in neoplastic progression. K ATP channels help maintain membrane polarity and linkages between K ATP channel activity and rates of GJIC have been established. The mechanistic relationship has not been fully elucidated. We report the effects of treatment with multiple K ATP antagonist compounds on GJIC in metastatic cell lines demonstrating an increase in communication rates following treatment with compounds possessing specificities towards the SUR2 subunit of K ATP. These effects remained consistent using cell lines with different expression levels of SUR1 and SUR2, suggesting possible off target effects on GJIC by these compounds. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 21133063
  • Author List

  • Bodenstine TM; Vaidya KS; Ismail A; Beck BH; Diers AR; Edmonds MD; Kirsammer GT; Landar A; Welch DR
  • Start Page

  • 27
  • End Page

  • 31
  • Volume

  • 586
  • Issue

  • 1