Enzymes of the Pentose Phosphate Pathway in Glutathione-Regulated Membrane Protection in β-Thalassaemia

Academic Article


  • The mass concentrations of whole blood reduced glutathione and catalytic activity concentrations of the enzymes, glucose-6-phosphate dehydrogenase (EC, glutathione reductase (EC and glutathione peroxidase (EC 1.11.9) were analysed in 25 cases of homozygous β-thalassaemia, 20 cases of heterozygous β-thalassaemia and 10 controls. The results showed a significant elevation of reduced glutathione and enzymes of the pentose phosphate pathway in homozygous β-thalassaemia, indicating the existence of an enzyme-regulated glutathione turnover system in the overt state to combat the augmented red cell membrane damage due to autoxidant threat. However, in heterozygous β-thalassaemia, reduced glutathione was increased, but there was no similar elevation of enzymes except for glutathione peroxidase. © 1992 Walter de Gruyter & Co.
  • Digital Object Identifier (doi)

    Author List

  • Ponnazhagan S; Sarkar R
  • Start Page

  • 481
  • End Page

  • 484
  • Volume

  • 30
  • Issue

  • 8