Expression of syndecan-1 is a sensitive marker for cutaneous plasmacytoma

Academic Article


  • Background: Cutaneous plasmacytoma is a well-recognized, yet infrequent, occurrence in multiple myeloma (MM). There are limitations in the morphologic assessment, and as such, the diagnosis presents some difficulty, particularly with the plasmablastic type. Methods: Pathology reports of 2357 patients with a diagnosis of MM were reviewed. Twenty patients yielded a total of 25 plasmacytomas, 10 of which were analyzed for syndecan-1 immunoreactivity. Bartl grade of bone marrow and cutaneous plasmacytoma was compared and immunoglobulin secretory status of the patients was assessed. Results: The incidence of cutaneous plasmacytoma was found to be 1 in 118 patients with MM. Immunoglobulin secretion was found to be predominantly IgG. There was a trend for the plasmacytoma Bartl grade to be equal to or greater than that of the corresponding bone marrow Bartl grade, suggesting a more aggressive phenotype in the metastatic lesion. Conclusion: Syndecan-1 was found to be a sensitive marker for plasmacytomas, independent of cytologic differentiation. © Blackwell Munksgaard 2003.
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    Author List

  • Bayer-Garner IB; Joseph L; Sanderson RD; Smoller BR
  • Start Page

  • 18
  • End Page

  • 22
  • Volume

  • 30
  • Issue

  • 1