Development and survival of th17 cells within the intestines: The influence of microbiome-and diet-derived signals

Academic Article

Abstract

  • Th17 cells have emerged as important mediators of host defense and homeostasis at barrier sites, particularly the intestines, where the greatest number and diversity of the microbiota reside. A critical balance exists between protection of the host from its own microbiota and pathogens and the development of immune-mediated disease. Breaches of local innate immune defenses provide critical stimuli for the induction of Th17 cell development, and additional cues within these tissues promote Th17 cell survival and/or plasticity. Normally, this results in eradication of the microbial threat and restitution of homeostasis. When dysregulated, however, Th17 cells can cause a range of immunemediated diseases, whether directed against Ags derived from the microbiota, such as in inflammatory bowel disease, or against self-Ags in a range of autoimmune diseases. This review highlights recent discoveries that provide new insights into ways in which environmental signals impact Th17 cell development and function in the intestines.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Chewning JH; Weaver CT
  • Start Page

  • 4769
  • End Page

  • 4777
  • Volume

  • 193
  • Issue

  • 10