Interplay between the TH 17 and TReg cell lineages: A (co-)evolutionary perspective

Academic Article


  • The origins of the adaptive immune system and the basis for its unique association with vertebrate species have been a source of considerable speculation. In light of recent advances in our understanding of the developmental and functional links between the induced regulatory T cell and T helper 17 cell lineages, and their specialized relationship to the gut, we speculate that the co-evolution of these adaptive immune pathways might have given primitive vertebrates a means to benefit from the diversification of their commensal microbiota. © 2009 Macmillan Publishers Limited. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Weaver CT; Hatton RD
  • Start Page

  • 883
  • End Page

  • 889
  • Volume

  • 9
  • Issue

  • 12