Purification and characterization of proteins excreted by cells infected with herpes simplex virus and their use in diagnosis

Academic Article


  • A virus-specific glycoprotein, excreted by rabbit kidney cells infected with herpes simplex virus, type 1, has been purified and radioiodinated. This problem has an electrophoretic mobility in polyacrylamide gels similar to that of one of the largest glycoproteins of the virions of herpes simplex virus (Molecular Weight ∼132,000) and shares antigenic determinants with an internal virion protein. After radioiodination, this glycoprotein can be used for the detection of virus-specific antigens in patients with herpes simplex virus encephalitis. © 1978.
  • Published In

  • Virology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Chen AB; Ben-Porat T; Whitley RJ; Kaplan AS
  • Start Page

  • 234
  • End Page

  • 242
  • Volume

  • 91
  • Issue

  • 2