CNS diseases associated with varicella zoster virus and herpes simplex virus infection. Pathogenesis and current therapy

Academic Article


  • The human herpesviruses, particularly herpes simplex virus (HSV) and varicella zoster virus (VZV), have long been associated with neurologic disorders. Since the first reports of herpes simplex encephalitis by the Mathewson Commission in 1926 and the subsequent description of the histopathologic changes seen in a case of herpes encephalitis, HSV has been recognized as the most common cause of sporadic fatal encephalitis in the United States. Varicella zoster virus, the causative agent in chickenpox and zoster (shingles), has also been associated with a variety of neurologic complications. It is the purpose of this article to discuss the central nervous system (CNS) disorders associated with both HSV and VZV infections and to indicate appropriate strategies for the diagnosis and management of these disorders.
  • Published In

  • Neurologic Clinics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Barnes DW; Whitley RJ
  • Start Page

  • 265
  • End Page

  • 283
  • Volume

  • 4
  • Issue

  • 1