Protective immunity against herpetic ocular disease in an outbred mouse model

Academic Article


  • Immunization of outbred mice by subdermal (footpad) inoculation with the F strain of herpes simplex virus type 1 (HSV-1) induces an immune response which protects the animals against herpetic ocular disease and encephalitis, and reduces the incidence of latent trigeminal ganglion infections following corneal challenge with the RE strain of HSV type 1. The protective effects are proportional to the dose of virus used for immunization. Heat-killed virus preparations also protected the mice against encephalitis and stromal keratitis, but failed to prevent epithelial keratitis and establishment of latency. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Metcalf JF; Whitley RJ
  • Start Page

  • 167
  • End Page

  • 171
  • Volume

  • 6
  • Issue

  • 1