Apical expression of herpes simplex virus type 2 glycoproteins in human neuroblastoma cells

Academic Article


  • The expression of herpes simplex virus type 2 (HSV-2) glycoproteins on the surface of human neuroblastoma cells has been investigated using Millipore Millicell culture plate inserts. Utilizing a modified radioimmunoassay, we learned that glycoproteins B, C, D, E, and I were expressed predominantly on the apical membrane domain of the infected neuroblastoma cells. The unidirectional transport of HSV-2 glycoproteins was substantiated by the analysis of extracellular glycoproteins released from neuroblastoma cells. The results suggest that the evaluated HSV-2 glycoproteins were transported primarily to the apical plasma membrane domain of human neuroblastoma cells. © 1991.
  • Published In

  • Virology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Nielsen LN; Whitley RJ; Chatterjee S
  • Start Page

  • 908
  • End Page

  • 910
  • Volume

  • 185
  • Issue

  • 2