Effect of recombinant human interferon α B/D (rHu-IFN-α B/D) in combination with acyclovir in experimental HSV-1 encephalitis

Academic Article


  • The efficacy of recombinant human interferon α B/D in experimental HSV- 1 encephalitis was investigated in the murine system. Recombinant Hu-IFN-α B/D significantly reduced the mortality in a mouse encephalitis model (about 30%, P=0.021), whereas natural mouse interferon was inactive. Combination of acyclovir with Hu-IFN-α B/D had an additive effect.
  • Published In

  • Antiviral Research  Journal
  • Digital Object Identifier (doi)

    Author List

  • Wintergerst U; Gangemi JD; Whitley RJ; Chatterjee S; Kern ER
  • Start Page

  • 75
  • End Page

  • 78
  • Volume

  • 44
  • Issue

  • 1