Sugars and alcohol: IgA-associated renal diseases in alcoholic cirrhosis

Academic Article

Abstract

  • Tissandi√© and colleagues report in this issue on their studies of IgA1 glycosylation and biological activities of IgA1-containing circulating immune complexes in patients with alcoholic cirrhosis who developed secondary renal disease with IgA deposits, secondary IgA nephropathy. Their seminal findings demonstrate abnormal glycosylation of IgA1 N-linked as well as O-linked glycans. Furthermore, their work reveals unique biological properties of immune complexes in these patients as compared with those in patients with primary IgA nephropathy. ¬© 2011 International Society of Nephrology.
  • Digital Object Identifier (doi)

    Author List

  • Novak J; Julian BA
  • Start Page

  • 1252
  • End Page

  • 1254
  • Volume

  • 80
  • Issue

  • 12