The genetics and immunobiology of IgA nephropathy

Academic Article


  • IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian populations and the most frequent form of primary glomerulonephritis among Europeans. Patients with IgAN develop characteristic IgA1-containing immune complexes that deposit in the glomerular mesangium, producing progressive kidney injury. Recent studies define IgAN as an autoimmune trait of complex architecture with a strong genetic determination. This Review summarizes new insights into the role of the O-glycosylation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, and the alternative complement pathway in the pathogenesis of IgAN.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Kiryluk K; Novak J
  • Start Page

  • 2325
  • End Page

  • 2332
  • Volume

  • 124
  • Issue

  • 6