Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

Academic Article

Abstract

  • Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40-deficient DCs with IL-12p40 homodimer (IL-12(p40)2) restores Mtb-induced DC migration and the ability of IL-12p40-deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogeninduced activation of pulmonary DCs. JEM © The Rockefeller University Press.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Khader SA; Partida-Sanchez S; Bell G; Jelley-Gibbs DM; Swain S; Pearl JE; Ghilardi N; DeSauvage FJ; Lund FE; Cooper AM
  • Start Page

  • 1805
  • End Page

  • 1815
  • Volume

  • 203
  • Issue

  • 7