Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A

Academic Article


  • Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to a specific cell-surface receptor. We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein-coupled receptor whose genetic ablation results in the development of autoimmunity. Activation of G2A by LPC increased intracellular calcium concentration, induced receptor internalization, activated ERK mitogen-activated protein kinase, and modified migratory responses of Jurkat T lymphocytes. This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Kabarowski JHS; Zhu K; Le LQ; Witte ON; Xu Y
  • Start Page

  • 702
  • End Page

  • 705
  • Volume

  • 293
  • Issue

  • 5530