Marginal zone B cells regulate antigen capture by marginal zone macrophages

Academic Article


  • The marginal zone (MZ) of the mouse spleen contains macrophages that express receptors that trap pathogens, including the scavenger receptor macrophage receptor with a collagenous structure and the C-type lectin specific intracellular adhesion molecule-grabbing nonintegrin receptor 1 (SIGN-R1). We previously reported that expression of SIGN-R1 was decreased in CD19-deficient mice. In this study, we demonstrate that SIGN-R1 is expressed on a subset of macrophage receptor with a collagenous structure (MARCO)+ macrophages. This subset is diminished when MZ B cells are absent due to either genetic developmental defects or following transient migration of B cells out of the MZ. When B cells return to the MZ, there is a delay in recovery of SIGN-R1-expressing macrophages. During this period, capture of Ficoll, which for the macrophages requires SIGN-R1, remains defective not only by the macrophages, but also by the B cells. Thus, MZ B cells regulate expression of molecules on macrophages that are important for trapping Ag, which, in turn, is required for Ag capture by the B cells.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 9381969
  • Author List

  • You Y; Myers RC; Freeberg L; Foote J; Kearney JF; Justement LB; Carter RH
  • Start Page

  • 2172
  • End Page

  • 2181
  • Volume

  • 186
  • Issue

  • 4