Complete sharing of light chain spectrotypes by murine IgM and IgG anti streptococcal antibodies

Academic Article

Abstract

  • In order to examine the diversity of antibody light chains, we have developed an analytic isoelectric focusing procedure which permits the routine analysis of L chains from antibodies raised in individual mice. We have used this technique to demonstrate that the light chains of IgM and IgG anti-group A streptococcal antibodies raised in SWR mice are probably shared. Interestingly, numerous light chain spectrotypes are shared between individual mice whose 7S antibody focusing patterns differ.
  • Authors

    Published In

    Pubmed Id

  • 2708363
  • Author List

  • Perlmutter RM; Briles DE; Davie JM
  • Start Page

  • 2161
  • End Page

  • 2166
  • Volume

  • 118
  • Issue

  • 6