Immune response deficiency of BSVS mice. II. Generalized deficiency to thymus‐dependent antigens

Academic Article

Abstract

  • BSVS mice gave abnormally low IgG responses to 5 thymus‐dependent antigens as well as a weak delayed‐type hypersensitivity (DTH) response to sheep red blood cells. In contrast to IgG, the IgM antibody responses of these mice were normal to three T‐independent antigens as well as to all five T‐dependent antigens. The low immune responsiveness of BSVS mice was also reflected in the low levels of IgG2a, IgG2b and IgG3 in their normal serum. The low T‐dependent immune responses may result from BSVS mice having been selectively bred for susceptibility to infection with St. Louis encephalitis virus and Salmonella. C57BL/6J mice, which are also highly susceptible to Salmonella, gave low immune responses similar to, but genetically distinct from, those of BSVS mice. The levels of Ig‐positive and theta‐positive cells were normal in BSVS and C57BL/6J mice. Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Briles DE; Perlmutter RM; Hansburg D; Little JR; Davie JM
  • Start Page

  • 255
  • End Page

  • 261
  • Volume

  • 9
  • Issue

  • 4