Salmonella typhimurium virulence genes necessary to exploit the Ity(s/s) genotype of the mouse

Academic Article


  • The studies described in this paper provide evidence that the pathogenesis of Salmonella typhimurium in mice is dependent on interactions between particular genotypes of the infected mice and the infecting Salmonella strain. This conclusion was based on data obtained by infecting a panel of BXD recombinant inbred mice with each of three S. typhimurium strains. One of the S. typhimurium strains was a transconjugant (WB500) produced in an interrupted mating between the two other strains, one (SR-11) of high and the other (LT2-Z) of low virulence for BALB/c mice. We found that strain WB500 appeared to have inherited from SR-11 a gene (or genes) which was required to exploit the Ity(s/s) genotype in mice. However, WB500 apparently lacked other SR-11 virulence gene(s), whose effect on the in vivo growth of SR-11 was independent of the Ity genotype of the mouse.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Benjamin WH; Turnbough CL; Posey BS; Briles DE
  • Start Page

  • 872
  • End Page

  • 878
  • Volume

  • 51
  • Issue

  • 3