IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection

Academic Article

Abstract

  • Although mice from almost all inbred strains produce IgM anti-DNA antibody in response to B cell mitogens, only (NZB x NZW)F1 mice and mice from other strains that are genetically predisposed to autoimmunity spontaneously produce anti-DNA antibody of the IgG isotype. Because (NZB x NZW)F1 mice display marked B cell hyperactivity, anti-DNA antibody production in these mice has been thought to result from spontaneous, polyclonal B cell activation. Although this may be true for IgM anti-DNA antibodies, our results demonstrate that IgG anti-DNA antibodies are not polyclonal. Rather, IgG anti-DNA autoantibodies within an individual autoimmune mouse are oligoclonal and somatically mutated. These results demonstrate that IgG anti-DNA autoantibodies are the products of clonally selective B cell stimulation and exhibit the same characteristics as secondary immune antibodies to conventional immunogens: they are IgG, they are clonally restricted, and they are somatically mutated.
  • Authors

    Published In

    Pubmed Id

  • 2290804
  • Author List

  • Marion TN; Bothwell ALM; Briles DE; Janeway CA
  • Start Page

  • 4269
  • End Page

  • 4274
  • Volume

  • 142
  • Issue

  • 12