Virulence of pneumococcal proteins on the inner ear

Academic Article


  • Objective: To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear. Main Outcome Measures: A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear. Results: Most of the animals inoculated with highdose pneumolysin or wild-type bacteria showed severe pathologic changes of the inner ears. The inner ears of most animals inoculated with surface protein A or surface antigen A-deficient bacteria appeared normal. Conclusions: Pneumococcal surface protein A and pneumococcal surface antigen A are 2 important virulence factors in inner ear damage secondary to pneumococcal otitis media. Mutation of these virulence factors results in less inner ear damage. ©2009 American Medical Association. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 39664
  • Author List

  • Schachern PA; Tsuprun V; Cureoglu S; Ferrieri P; Briles DE; Paparella MM; Juhn S
  • Start Page

  • 657
  • End Page

  • 661
  • Volume

  • 135
  • Issue

  • 7