Influenza A virus facilitates Streptococcus pneumoniae transmission and disease

Academic Article

Abstract

  • Streptococcus pneumoniae (the pneumococcus) kills ∼1.6 million people annually. Pneumococcal infections predominantly manifest as pneumonia, sepsis, meningitis, and otitis media. S. pneumoniae is also a member of the normal nasopharyngeal flora, colonizing up to 80% of children. Infection with influenza A virus (IAV) has been associated with both pneumococcal disease and transmission. However, to date no animal model has been available to investigate the role of IAV in the spread of S. pneumoniae. Here we investigate pneumococcal-influenza synergism with a particular focus on the role of IAV on pneumococcal transmission. Infant mice were colonized with S. pneumoniae and subsequently infected with IAV 3 d later. Using this novel model we show increased pneumococcal colonization and disease in the presence of IAV. Notably, in vivo imaging showed that IAV was essential for the transmission of S. pneumoniae from colonized ("index") mice to their naive cohoused littermates ("contacts"). Transmission occurred only when all mice were infected with IAV and was prevented when an IAV-neutralizing antibody was used to inhibit IAV replication in either index mice or contact mice. Together, these data provide novel insights into pneumococcal-influenza synergism and may indicate a previously unappreciated role of IAV in the spread of S. pneumoniae. © FASEB.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 12889631
  • Author List

  • Diavatopoulos DA; Short KR; Price JT; Wilksch JJ; Brown LE; Briles DE; Strugnell RA; Wijburg OL
  • Start Page

  • 1789
  • End Page

  • 1798
  • Volume

  • 24
  • Issue

  • 6