Streptococcus pneumoniae isolates from middle ear fluid and nasopharynx of children with acute otitis media exhibit phase variation

Academic Article


  • Pneumococcal phase variation of 37 middle ear and 31 nasopharyngeal isolates obtained from children with acute otitis media was examined in the absence of intervening culture. The fraction of the opaque colonies was significantly higher in middle ear isolates than in nasopharyngeal isolates. The difference is probably the result of the pneumococci adapting to differential selective environments. Copyright © 2011, American Society for Microbiology.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 327642
  • Author List

  • Arai J; Hotomi M; Hollingshead SK; Ueno Y; Briles DE; Yamanaka N
  • Start Page

  • 1646
  • End Page

  • 1649
  • Volume

  • 49
  • Issue

  • 4