Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children

Academic Article

Abstract

  • To characterize a host polygenic profile associated with susceptibility to human T lymphotropic virus type I (HTLV-I) infection, we examined common variants in 11 immune-related genes among Jamaican children born to HTLV-1-seropositive mothers. Compared with HTLV-I seronegatives, haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal pro virus load and duration of breast-feeding (odds ratio [OR], 4.5 [95% confidence interval {CI}, 1.2-17.6], and OR, 3.5 [95% CI, 1.4-9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection. © 2006 by the Infectious Diseases Society of America. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Brown EE; Brown BJ; Yeager M; Welch R; Cranston B; Hanchard B; Hisada M
  • Start Page

  • 1565
  • End Page

  • 1569
  • Volume

  • 194
  • Issue

  • 11