Molecular conjugate-mediated gene transfer into isolated human and transplanted rat kidneys

Academic Article


  • Technically, renal transplantation has been feasible for over four decades. However, immunological injury to the transplanted kidney continues to be the leading cause of graft loss. While current immunosuppressive protocols yield a 1-year graft survival of >90%, the trade off is increased risks from nephrotoxicity to manifestations of long-term immunosuppression. We have developed techniques which would allow genetic manipulation of the donor kidney while utilizing current procurement and preservation protocols.
  • Authors

    Author List

  • Zeigler ST; Kerby JD; Thompson JA
  • Start Page

  • 508
  • End Page

  • 513
  • Volume

  • 5
  • Issue

  • 6