Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of Pneumocystis pneumonia

Academic Article


  • CB4 CB25 FoxP3 regulatory T cells are decreased in patients infected with HW and have been shown to be critical in mediating Ag tolerance in the lung. Because a subset of Pneumocystis-infected individuals develop substantial lung injury, which can be modeled in immune reconstituted scid mice, we used mouse models of Pneumocystis carinii to investigate the role of regulatory T cells in opportunistic infection and immune reconstitution. In this study, we show that CD4 CD25 FoxP3 cells are part of the host response to Pneumocystis in CD4 T cell-intact mice. Moreover, lung injury and proinflammatory Th1 and Th2 cytokine levels in the bronchoalveolar lavage fluid and lung homogenate were increased following CD4 CD25 immune reconstitution in Pneumocystis-infected SCID mice but not in CD4 CD25 T cell-reconstituted animals. The ability of CD4 CD25 T cells to control inflammation and injury during the course of Pneumocystis was confirmed by treatment of wild-type C57BL/6 mice with anti-CD25 mAb. These data show that CD4 CD25 T cells control pulmonary inflammation and lung injury associated with Pneumocystis infection both in the setting of immune reconstitution as well as new acquisition of infection. Copyright © 2006 by The American Association of Immunologists, Inc. + + + + + + + + - + + + + + +
  • Published In

    Digital Object Identifier (doi)

    Author List

  • McKinley L; Logar AJ; McAllister F; Zheng M; Steele C; Kolls JK
  • Start Page

  • 6215
  • End Page

  • 6226
  • Volume

  • 177
  • Issue

  • 9